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KMID : 0812020060120010031
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Korean Journal of Neurogastroenterology and Motility
2006 Volume.12 No. 1 p.31 ~ p.34
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The Effect of Tadalafil on Gastric Emptying of Healthy Adults
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Kim Min-Su
Chang Jin-Hyuck
Kim Ek-Seong
Hwang Seoung-Joon
Jahng Jae-Hoon
Kim Seung-Min
Ryu Young-Hoon
Park Hyo-Jin
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Abstract
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Background/Aims: In a previous study we demonstrated an influence of sildenafil, a phosphodiesterase (PDE) type 5 inhibitor, on intragastric food maldistribution without affecting total gastric emptying. In this we wanted to determine the effect of tadalafil (cialis ®), which has longer duration of action than sildenafil, on gastric emptying.
Methods: Eight male (mean age, 26.4 yrs) healthy volunteers were selected. Total T1/2 (min) was measured to assess total gastric emptying before, 30 minutes and 24 hours after tadalafil intake. Proximal T1/2 (min), initial proximal activity (%)-radioactiviy measured in the proximal body of the stomach immediately after food ingestion-, and the maximal distal content (%)-the highest radioactiviy measured in the distal body of the stomach was measured as indicators of intragastric food distribution.
Results: There were no significant differences in total T1/2 (min), proximal T1/2 (min), initial proximal activity (%) and maximal distal content (%) before and 30 minutes and 24 hrs after intake of tadalafil.
Conclusions: The recently launched PDE5 inhibitor, tadalafil, has no significant influence on total gastric emptying or intragastric food distribution. (Kor J Neurogastroenterol Motil 2006;12:31-34)
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KEYWORD
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Phosphodiesterase type 5 inhibitor, Gastric emptying, Intragastric food distribution, Tadalafil
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